Endocrine Abstracts

Introduction: Finding the optimal levothyroxine (LT4) dose regime to ameliorate the abnormally low levels of natural thyroid hormones, especially for thyroidectomized patients, is still challenging. Many researchers have studied various LT4 dosage regimen clinically; and ultimately, they proposed multiple variables affecting LT4 requirements including age, gender, body weight, body mass index (BMI), and body surface area (BSA). However, prescribing the most appropriate LT4 dos...

Introduction: Several levothyroxine (LT4) monotherapy dose regimen have been already proposed by different medical scientists which may result in various daily LT4 doses. Comparing the consequences of such dose regimen are rather difficult since they have to be applied on either the same patient or a large study groups. Therefore, a straight forward method would be to simulate the plasma level of thyroid hormones of virtual-patients treated by various dose regimen.<p class...

Introduction: Hyperparathyroidism happens when one or more of parathyroid glands secret excessive parathyroid hormone, causing calcium levels in blood to rise. A diagnosis may be missed or delayed because there are no symptoms or they are vague, like depression, tiredness, losing your appetite in addition to hypercalcaemia symptoms e.g. vomiting, bone and joint pain, dehydration, hypertension, etc. Surgery to remove the parathyroid gland is usually the only way of treating pri...

Clinicians recognize patients persistently experience residual symptoms of thyrotoxicosis or hypothyroidism etc. despite having achieved circulating levels of TSH and FT4 within the conventional normal ranges. In fact, many pathological conditions affect preferred TSH and FT4. In addition, evidences indicate that the laboratory-quoted normal thyroid hormones as well as TSH reference range could not be always appropriate for everyone in clinical practice. In neonates, infants, ...

Conventionally, physicians adjust LT4 dose by clinical estimation based on their experiences and available guidelines; however, no computational algorithm exists to support their decisions. The objective of this study is to build an artificial decision support system utilizing fuzzy logic to propose a proper LT4 dosage regimen. We used THYROSIM software as the model of human thyroid hormone regulation to simulate a virtual thyroidectomized patient, setting the secretion rates ...

Background: current studies reported that pregnancy in women with hypopituitarism is rare and several obestristics and endocrinologic complications must resolve for successful pregnancy among these women. Here we report one woman with hypopituitarism who became pregnant after hormonal replacement therapy.Method: A therapeutic strategy for 34 years old pregnant women as known case of pituitary surgery and completed pan hypopituitarism was designed. We per...